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Articles (52)
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1

Structural insights into RNA recognition and activation of RIG-I-like receptors

Daisy W Leung, Gaya K Amarasinghe

Journal:

Current Opinion in Structural Biology

Année:

2012

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2012

2

Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory Domain

Daisy W. Leung, Reed S. Shabman, Mina Farahbakhsh, Kathleen C. Prins, Dominika M. Borek, Tianjiao Wang, Elke Mühlberger, Christopher F. Basler, Gaya K. Amarasinghe

Journal:

Journal of Molecular Biology

Année:

2010

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2010

3

Filoviral Immune Evasion Mechanisms

Ramanan, Parameshwaran, Shabman, Reed S., Brown, Craig S., Amarasinghe, Gaya K., Basler, Christopher F., Leung, Daisy W.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 642 KB

english, 2011

4

Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses

Bào, Yīmíng, Amarasinghe, Gaya, Basler, Christopher, Bavari, Sina, Bukreyev, Alexander, Chandran, Kartik, Dolnik, Olga, Dye, John, Ebihara, Hideki, Formenty, Pierre, Hewson, Roger, Kobinger, Gary, Ler

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 837 KB

english, 2017

5

Internal dynamics control activation and activity of the autoinhibited Vav DH domain

Li, Pilong, Martins, Ilídio R S, Amarasinghe, Gaya K, Rosen, Michael K

Journal:

Nature Structural and Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 529 KB

english, 2008

6

NMR structure of stem-loop SL2 of the HIV-1 Ψ RNA packaging signal reveals a novel A-U-A base-triple platform

Gaya K Amarasinghe, Roberto N De Guzman, Ryan B Turner, Michael F Summers

Journal:

Journal of Molecular Biology

Année:

2000

Langue:

english

Fichier:

PDF, 395 KB

english, 2000

7

NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the Ψ-RNA packaging signal. implications for genome recognition

Gaya K Amarasinghe, Roberto N De Guzman, Ryan B Turner, Kalola J Chancellor, Zeng Rong Wu, Michael F Summers

Journal:

Journal of Molecular Biology

Année:

2000

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2000

8

Stem-loop SL4 of the HIV-1 Ψ RNA packaging signal exhibits weak affinity for the nucleocapsid protein. structural studies and implications for genome recognition

Gaya K. Amarasinghe, Jing Zhou, Matthew Miskimon, Kalola J. Chancellor, Jasmine A. McDonald, Akida G. Matthews, Robyn R. Miller, Michael D. Rouse, Michael F. Summers

Journal:

Journal of Molecular Biology

Année:

2001

Langue:

english

Fichier:

PDF, 358 KB

english, 2001

9

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

Bingke Yu, Ilídio R.S. Martins, Pilong Li, Gaya K. Amarasinghe, Junko Umetani, Martin E. Fernandez-Zapico, Daniel D. Billadeau, Mischa Machius, Diana R. Tomchick, Michael K. Rosen

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 869 KB

english, 2010

10

Molecular mechanisms of viral inhibitors of RIG-I-like receptors

Daisy W. Leung, Christopher F. Basler, Gaya K. Amarasinghe

Journal:

Trends in Microbiology

Année:

2012

Langue:

english

Fichier:

PDF, 4.40 MB

english, 2012

11

Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein

Rosen, Michael K., Li, Pilong, Martins, Ilidio R.S., Amarasinghe, Gaya K., Yu, Bingke, Umetani, Junko

Journal:

Biophysical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 36 KB

english, 2009

12

Mutual Antagonism between the Ebola Virus VP35 Protein and the RIG-I Activator PACT Determines Infection Outcome

Luthra, Priya, Ramanan, Parameshwaran, Mire, Chad E., Weisend, Carla, Tsuda, Yoshimi, Yen, Benjamin, Liu, Gai, Leung, Daisy W., Geisbert, Thomas W., Ebihara, Hideki, Amarasinghe, Gaya K., Basler, Chri

Journal:

Cell Host & Microbe

Année:

2013

Langue:

english

Fichier:

PDF, 977 KB

english, 2013

13

Evasion of Interferon Responses by Ebola and Marburg Viruses

Basler, Christopher F., Amarasinghe, Gaya K.

Journal:

Journal of Interferon & Cytokine Research

Année:

2009

Langue:

english

Fichier:

PDF, 391 KB

english, 2009

14

A Calcium-Fortified Viral Matrix Protein

Amarasinghe, Gaya K., Dutch, Rebecca Ellis

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 253 KB

english, 2014

15

The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

Edwards, Megan R., Johnson, Britney, Mire, Chad E., Xu, Wei, Shabman, Reed S., Speller, Lauren N., Leung, Daisy W., Geisbert, Thomas W., Amarasinghe, Gaya K., Basler, Christopher F.

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2014

16

Development of RNA Aptamers Targeting Ebola Virus VP35

Binning, Jennifer M., Wang, Tianjiao, Luthra, Priya, Shabman, Reed S., Borek, Dominika M., Liu, Gai, Xu, Wei, Leung, Daisy W., Basler, Christopher F., Amarasinghe, Gaya K.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 3.10 MB

english, 2013

17

Acidic Region Tyrosines Provide Access Points for Allosteric Activation of the Autoinhibited Vav1 Dbl Homology Domain †

Amarasinghe, Gaya K., Rosen, Michael K.

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 314 KB

english, 2005

18

Ebolavirus VP35 is a multifunctional virulence factor

Leung, Daisy W., Prins, Kathleen C., Basler, Christopher F., Amarasinghe, Gaya K.

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 1.06 MB

english, 2010

19

Defining a Two-pronged Structural Model for PB1 (Phox/Bem1p) Domain Interaction in Plant Auxin Responses

Korasick, David A., Chatterjee, Srirupa, Tonelli, Marco, Dashti, Hesam, Lee, Soon Goo, Westfall, Corey S., Fulton, D. Bruce, Andreotti, Amy H., Amarasinghe, Gaya K., Strader, Lucia C., Jez, Joseph M.

Journal:

Journal of Biological Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 7.99 MB

english, 2015

20

An Upstream Open Reading Frame Modulates Ebola Virus Polymerase Translation and Virus Replication

Shabman, Reed S., Hoenen, Thomas, Groseth, Allison, Jabado, Omar, Binning, Jennifer M., Amarasinghe, Gaya K., Feldmann, Heinz, Basler, Christopher F., Whelan, Sean P. J.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 1.38 MB

english, 2013

21

Human and murine IFIT1 do not restrict infection of negative sense RNA viruses of the orthomyxoviridae, bunyaviridae, and filoviridae families

Pinto, Amelia K., Williams, Graham D., Szretter, Kristy J., White, James P., Proença-Módena, José Luiz, Liu, Gai, Olejnik, Judith, Brien, James D., Ebihara, Hideki, Mühlberger, Elke, Amarasinghe, Gaya

Journal:

Journal of Virology

Année:

2015

Langue:

english

Fichier:

PDF, 3.97 MB

english, 2015

22

Ebola Virus VP35 Interaction with Dynein LC8 Regulates Viral RNA Synthesis

Luthra, Priya, Jordan, David S., Leung, Daisy W., Amarasinghe, Gaya K., Basler, Christopher F., Lyles, D. S.

Journal:

Journal of Virology

Année:

2015

Langue:

english

Fichier:

PDF, 779 KB

english, 2015

23

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

Edwards, Megan R., Liu, Gai, Mire, Chad E., Sureshchandra, Suhas, Luthra, Priya, Yen, Benjamin, Shabman, Reed S., Leung, Daisy W., Messaoudi, Ilhem, Geisbert, Thomas W., Amarasinghe, Gaya K., Basler,

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2016

24

When your cap matters: structural insights into self vs non-self recognition of 5′ RNA by immunomodulatory host proteins

Leung, Daisy W, Amarasinghe, Gaya K

Journal:

Current Opinion in Structural Biology

Année:

2016

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2016

25

Taxonomy of the orderMononegavirales: update 2016

Afonso, Claudio L., Amarasinghe, Gaya K., Bányai, Krisztián, Bào, Yīmíng, Basler, Christopher F., Bavari, Sina, Bejerman, Nicolás, Blasdell, Kim R., Briand, François-Xavier, Briese, Thomas, Bukreyev,

Journal:

Archives of Virology

Année:

2016

Langue:

english

Fichier:

PDF, 438 KB

english, 2016

26

Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses

Johnson, Britney, Li, Jing, Adhikari, Jagat, Edwards, Megan R., Zhang, Hao, Schwarz, Toni, Leung, Daisy W., Basler, Christopher F., Gross, Michael L., Amarasinghe, Gaya K.

Journal:

Journal of Molecular Biology

Année:

2016

Langue:

english

Fichier:

PDF, 817 KB

english, 2016

27

Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses

Chatterjee, Srirupa, Basler, Christopher F., Amarasinghe, Gaya K., Leung, Daisy W.

Journal:

Journal of Molecular Biology

Année:

2016

Langue:

english

Fichier:

PDF, 2.93 MB

english, 2016

28

Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials

Postler, Thomas S., Clawson, Anna N., Amarasinghe, Gaya K., Basler, Christopher F., Bavari, Sina, Benkő, Mária, Blasdell, Kim R., Briese, Thomas, Buchmeier, Michael J., Bukreyev, Alexander, Calisher,

Journal:

Systematic Biology

Année:

2016

Langue:

english

Fichier:

PDF, 425 KB

english, 2016

29

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability

Schwarz, Toni M., Edwards, Megan R., Diederichs, Audrey, Alinger, Joshua B., Leung, Daisy W., Amarasinghe, Gaya K., Basler, Christopher F., Lyles, Douglas S.

Journal:

Journal of Virology

Année:

2017

Langue:

english

Fichier:

PDF, 4.16 MB

english, 2017

30

A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35–NP Interface

Liu, Gai, Nash, Peter J., Johnson, Britney, Pietzsch, Colette, Ilagan, Ma. Xenia G., Bukreyev, Alexander, Basler, Christopher F., Bowlin, Terry L., Moir, Donald T., Leung, Daisy W., Amarasinghe, Gaya

Journal:

ACS Infectious Diseases

Année:

2017

Langue:

english

Fichier:

PDF, 4.14 MB

english, 2017

31

Taxonomy of the order Mononegavirales: update 2017

Amarasinghe, Gaya K., Bào, Yīmíng, Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolás, Blasdell, Kim R., Bochnowski, Alisa, Briese, Thomas, Bukreyev, Alexander, Calisher, Charles H.

Journal:

Archives of Virology

Année:

2017

Langue:

english

Fichier:

PDF, 473 KB

english, 2017

32

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis

Xu, Wei, Luthra, Priya, Wu, Chao, Batra, Jyoti, Leung, Daisy W., Basler, Christopher F., Amarasinghe, Gaya K.

Journal:

Nature Communications

Année:

2017

Langue:

english

Fichier:

PDF, 2.02 MB

english, 2017

33

Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication

Williams, Graham D., Townsend, Dana, Wylie, Kristine M., Kim, Preston J., Amarasinghe, Gaya K., Kutluay, Sebla B., Boon, Adrianus C. M.

Journal:

Nature Communications

Année:

2018

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2018

34

Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability

Johnson, Britney, VanBlargan, Laura A., Xu, Wei, White, James P., Shan, Chao, Shi, Pei-Yong, Zhang, Rong, Adhikari, Jagat, Gross, Michael L., Leung, Daisy W., Diamond, Michael S., Amarasinghe, Gaya K.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 4.04 MB

english, 2018

35

Taxonomy of the order Mononegavirales: update 2018

Amarasinghe, Gaya K., Aréchiga Ceballos, Nidia G., Banyard, Ashley C., Basler, Christopher F., Bavari, Sina, Bennett, Andrew J., Blasdell, Kim R., Briese, Thomas, Bukreyev, Alexander, Caì, Yíngyún, Ca

Journal:

Archives of Virology

Année:

2018

Langue:

english

Fichier:

PDF, 951 KB

english, 2018

36

Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange

Johnson, Britney, McConnell, Patrick, Kozlov, Alex G., Mekel, Marlene, Lohman, Timothy M., Gross, Michael L., Amarasinghe, Gaya K., Cooper, John A.

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 3.16 MB

english, 2018

37

Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms

Warfield, Kelly L, Howell, Katie A, Vu, Hong, Geisbert, Joan, Wong, Gary, Shulenin, Sergey, Sproule, Stephanie, Holtsberg, Frederick W, Leung, Daisy W, Amarasinghe, Gaya K, Swenson, Dana L, Bavari, Si

Journal:

The Journal of Infectious Diseases

Année:

2018

Langue:

english

Fichier:

PDF, 319 KB

english, 2018

38

Aptamers in Virology: Recent Advances and Challenges

Binning, Jennifer M., Leung, Daisy W., Amarasinghe, Gaya K.

Journal:

Frontiers in Microbiology

Année:

2012

Langue:

english

Fichier:

PDF, 1.14 MB

english, 2012

39

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes

Edwards, Megan R., Liu, Hejun, Shabman, Reed S., Ginell, Garrett M., Luthra, Priya, Ramanan, Parmeshwaran, Keefe, Lisa J., Köllner, Bernd, Amarasinghe, Gaya K., Taylor, Derek J., Leung, Daisy W., Basl

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2018

40

Applications of parameterized NMR spin systems of small molecules

Dashti, Hesam, Wedell, Jonathan R., Westler, William M., Tonelli, Marco, Aceti, David John, Amarasinghe, Gaya K., Markley, John L., Eghbalnia, Hamid R.

Journal:

Analytical Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 394 KB

english, 2018

41

Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation

Klein, Roger D., Shu, Qin, Cusumano, Zachary T., Nagamatsu, Kanna, Gualberto, Nathaniel C., Lynch, Aaron J. L., Wu, Chao, Wang, Wenjie, Jain, Neha, Pinkner, Jerome S., Amarasinghe, Gaya K., Hultgren,

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 3.00 MB

english, 2018

42

Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets

Basler, Christopher F., Krogan, Nevan J., Leung, Daisy W., Amarasinghe, Gaya K.

Journal:

Antiviral Research

Année:

2018

Langue:

english

Fichier:

PDF, 8.13 MB

english, 2018

43

Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities

Knoverek, Catherine R., Amarasinghe, Gaya K., Bowman, Gregory R.

Journal:

Trends in Biochemical Sciences

Année:

2018

Langue:

english

Fichier:

PDF, 3.22 MB

english, 2018

44

Taxonomy of the order Mononegavirales: update 2019

Amarasinghe, Gaya K., Ayllón, María A., Bào, Yīmíng, Basler, Christopher F., Bavari, Sina, Blasdell, Kim R., Briese, Thomas, Brown, Paul A., Bukreyev, Alexander, Balkema-Buschmann, Anne, Buchholz, Urs

Journal:

Archives of Virology

Année:

2019

Langue:

english

Fichier:

PDF, 804 KB

english, 2019

45

Backbone resonance assignments and secondary structure of Ebola nucleoprotein 600–739 construct

Lee, Woonghee, Tonelli, Marco, Wu, Chao, Aceti, David J., Amarasinghe, Gaya K., Markley, John L.

Journal:

Biomolecular NMR Assignments

Année:

2019

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2019

46

Ebola Virus Replication Stands Out

Wang, Wenjie, Wu, Chao, Amarasinghe, Gaya K., Leung, Daisy W.

Journal:

Trends in Microbiology

Année:

2019

Langue:

english

Fichier:

PDF, 179 KB

english, 2019

47

Sudan Ebolavirus VP35-NP Crystal Structure Reveals a Potential Target for Pan-Filovirus Treatment

Landeras-Bueno, Sara, Oda, Shun-ichiro, Norris, Michael J., Li Salie, Zhe, Guenaga, Javier, Wyatt, Richard T., Saphire, Erica Ollmann, Amarasinghe, Gaya, Smithgall, Thomas E.

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 2.77 MB

english, 2019

48

Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription

Ivanov, Andrey, Ramanathan, Palaniappan, Parry, Christian, Ilinykh, Philipp A., Lin, Xionghao, Petukhov, Michael, Obukhov, Yuri, Ammosova, Tatiana, Amarasinghe, Gaya K., Bukreyev, Alexander, Nekhai, S

Journal:

Cellular and Molecular Life Sciences

Année:

2019

Langue:

english

Fichier:

PDF, 5.57 MB

english, 2019

49

Small molecule compounds that inhibit antioxidant response gene expression in an inducer-dependent manner

Edwards, Megan R., Liu, Gai, De, Sampriti, Sourimant, Julien, Pietzsch, Colette, Johnson, Britney, Amarasinghe, Gaya K., Leung, Daisy W., Bukreyev, Alexander, Plemper, Richard K., Aron, Zachary, Bowli

Journal:

ACS Infectious Diseases

Année:

2020

Langue:

english

Fichier:

PDF, 62.03 MB

english, 2020

50

Small molecule compounds that inhibit antioxidant response gene expression in an inducer-dependent manner

Edwards, Megan R., Liu, Gai, De, Sampriti, Sourimant, Julien, Pietzsch, Colette, Johnson, Britney, Amarasinghe, Gaya K., Leung, Daisy W., Bukreyev, Alexander, Plemper, Richard K., Aron, Zachary, Bowli

Journal:

ACS Infectious Diseases

Année:

2020

Fichier:

PDF, 62.03 MB

2020